What is comparative sequencing?

Question

What is comparative sequencing?

Answer 1

It is pretty well known that most organisms have many genes in common.  The gene "eyeless" is in all mammals and can even be found in fruit flies.  Some of the growth regulating genes are found in virtually all organisms.

While these genes may have the same function the exact sequence of nucleic acids in them many be different over much of their length. In most cases though some regions have the same, or almost the same sequence of nucleic acids.  These are called "conserved" and are pretty obviously the important bits.

A comparison of genes controlling growth in dogs and in humans will show that they are nearly identical.  Corresponding genes in wheat and rice are nearly identical, and some regions of these genes in wheat and humans are the same.  

Comparing the sequences of one organism to another could reveal evolutionary relationships.  

In addition, comparison of the "junk DNA" also shows that for instance common ancestors of humans and chimpanzees were infected by a number of different retroviruses.  These viruses have inserted DNA coding for their own coat proteins etc into the genome of the host organism, but were inactivated. There are several of these retro-viral sequences in corresponding parts of the chimp, and human genomes. This fact has recently emerged from a comparison of retro-viral, chimp. and human genomes.

Answer 2

visit these sites: (u will get a lot of information)

www.ornl.gov/sci/techresources/Human_G...

www.sanger.ac.uk/Projects/Escherichia_...

www.nsf.gov/pubs/2006/nsf06555/nsf0655...

www.ncbi.nlm.nih.gov/pubmed/15718282

www.nature.com/nrg/journal/v9/n4/full/nr...

www.pnas.org/cgi/content/abstract/102/...

www.eurofinsdna.com/products-services/...

www.plantcell.org/cgi/content/full/18/...

www.genome.org/cgi/content/abstract/12...

malaria.wellcome.ac.uk/doc_WTD023854.h...

www.genetics.org/cgi/content/abstract/...

www.ncbi.nlm.nih.gov/pubmed/14694903

www.genome.gov/26525249

www.genecodes.com/sequencher/tutorials...

www.jimmunol.org/cgi/content/abstract/...

www.biosciencetechnology.com/ShowPR~PU...

jcm.asm.org/cgi/content/abstract/43/8/...

sageke.sciencemag.org/cgi/content/abst...

www.ingentaconnect.com/content/ap/me/1...

www.bio-computing.org/showabstract.php...

these sites should help u!

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~miley cyrus~