What is meant by "central administration" of a drug.?

Question

The orexin/hypocretin system was initially suggested to be primarily involved in the stimulation of food intake, based on the finding that ==> central administration <== of orexin A/hypocretin-1 increases food intake.

Answer 1

Sorry to the ICU person above, but in this context it means that the orexin and hypocretin were administered directly into the brain, probably into the hypothalamus; and at the very least into the ventricular system.

Answer 2

Central administration means the &quot;drug&quot; is infused into a central vein such as the subclacian, internal jugular, or vena cava. It requires a special, long IV catheter