What is the effect of acetylcholine on skeletel muscle fiber ends?

Question

What is the effect of acetylcholine on skeletel muscle fiber ends?

Answer 1

It stimulates muscular contraction by depolarining the motor plates on muscle fibres. This leads to calcium flooding the myocyte and actin and myosin interacting to yield a contraction of the sarcomere (muscle cell segment)

From http://www.bmb.leeds.ac.uk/illingworth/m...

Voluntary muscle cells are electrically isolated from each other, and respond only to direct instructions from a particular motor neurone via the motor end plate. They have nicotinic acetylcholine receptors, which are ligand-gated sodium channels concentrated in a specialised region of the muscle sarcolemma beneath the axon terminus. These ion channels respond to acetylcholine (secreted from the nerve) by depolarising the muscle sarcolemma near the motor end plate. The depolarisation triggers voltage-gated sodium channels which spread the excitation over the remainder of the cell.

-----

Details can be found under "Muscle Contraction" at http://www.ncbi.nlm.nih.gov/books/bv.fcg...