For me it has to be Magnolia, hands down. The final shot is of heroin addict Claudia, Melora Walters, sitting up in a bed in tears after a series of insane events with Officer Jim Kurring, John C. Reilly, walking towards the foot of the bed and speaking too softly to hear through Aimee Mann's ballad "Save Me" playing over the background. The conversation is nonspecific but one we've all said or heard at one point in our lives. Just when the song breaks into it's main chorus Claudia looks right into the camera with glassy eyes and smiles. Then black and rolling credits. Shakes me up every time.
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