What medication is worse on your liver methotrxate or accutane?

Question

What medication is worse on your liver methotrxate or accutane?

Answer 1

Both have risks but methotrexate is indicated as the more dangerous of the two. Both can cause hepatotoxicity but neither have a causal relationship to the condition. That is to say, there are no guarantees that you'll experience liver damage just from a regimen of one or the other (not both). Follow the prescribed schedule exactly, be careful with drug interactions (even the ones you don't think twice about), and don't drink alcohol.