What organelle's action is blocked by grapefruit juice making it so drugs are not properly detoxified in us?

Question

Thank you Merlin's feline!

Answer 1

the enzymes involved in the detoxication of many compounds are called cytochromes P-450 and there are many classes of them.They are located principally ijn the liver endoplasmic reticulum and the inner membrane of the mitochondrion. A subset of the cytochrome P-450 called CYP 3A4 is inhibited by certain compounds in grapefruit juice preventing normal detoxication of a variety of drugs