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What provides the template/model/blueprints to determine protein structure?

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What provides the template/model/blueprints to determine protein structure?

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  1. Naughty naughty naughty


  2. DNA is converted to RNA, and RNA is translated into a sequence of a amino acids in the ribosome.  Amino acids have different moieties ("R" groups), which differ in their acidity/basicity, hydrophobicity, and polarity.  The protein begins folding into its native state as it exits the ribosome based on these properties, as well as hydrogen bonds, electrostatic interactions (polar-polar), and sometimes disulfide bonds (between the sulfur groups found in cysteine molecules).  

    The primary driving force, however, is hydrophobicity (whether the molecules prefer a polar solvent, such as water, or a non-polar solvent).  In a physiological environment (mostly water) the "R" groups that are hydrophilic (water-loving) will remain exposed to the exterior while the hydrophobic groups (water-fearing) will gravitate toward other amino acids (perhaps in the center of the protein).

    An exact, predictable mechanism for protein folding, however, is not known.  Protein folding is a matter of great scientific interest and debate and discovery of a reproducible way to predict protein structure based on its amino acid sequence is considered by some to be the "holy grail" of biophysics.

  3. Your DNA....in short, messenger RNA copies the DNA.  the mRNA then leaves the nucleus and hooks up with a ribosome; this complex has a series of 3 base codons which code for different amino acids, as the ribosome "reads" the mRNA, different translation RNA's bring the matching amino acid; a chain of amino acids is a protein

  4. messenger RNA which is transcribed from DNA

  5. Well, depends on the extent you're looking for. Ultimately, all levels of protein structure save for post-translational folding are done as a result of the primary structure - that is, the amino acids that transcribe it. Therefore, you can safely say that the template is the DNA itself (or the mRNA, depending on how you look at it).

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