Whats the pathophysiology of benign prostatic hyperplasia ?

Question

whats the pathophysiology of benign prostatic hyperplasia? it is more easier for me to understand a diagramed pathophysiology of the said disease.. but narrative form is ok.. thanks for helping..

Answer 1

PATHOPHYSIOLOGY:

Schematic Diagram: This is our case presentation for our midterms.

First:  Due to Aging

                I

  Low Testosterone Level

                I

  High Estradiol (Estrogen)Level

                I

   Obstruction of Urethra

                I

   Urinary retention (dysuria(difficulty of urination), oliguria, anuria)

->The cause of BPH is uncertain up to this point of time. However, lifestyle is a big factor in developing BPH. Based on our research, drinking too much alcohol causes BPH, because beers can increase the estradiol level and increased estradiol level is the only reason why men develops BPH. Furthermore, the testosterone level of the males when they reached 30 years old starts to convert to estrogen by amylase.  

Answer 2

jazz- Because the answer to your question is very long, I'll try to share some important features.  The male prostate gland is located below the bladder. The seminal vesicles (containing sperm in s***n) are located posterior to the prostate. The urethra exits from the bladder and goes through the prostate before exiting to the penile urethra (pee hoile).

The normal prostate is composed of glands and stroma. The glands are lined mucin-secreting epithelium. The fibromuscular stroma between the glands accounts for about half of the volume of the prostate.  A prostate is about the size of a walnut.

Acute prostatitis (inflammation) is not common. Causative agents include bacteria similar to those causing urinary tract infections, as well as Neisseria gonorrheae. A related complication of prostatic abscess is uncommon. The edema and slight enlargement of the prostate with acute inflammation do not generally cause major symptoms, but may be associated with some pain on urination.

Chronic prostatitis may follow acute prostatitis. In some cases, bacteria can be cultured from urine that indicate the cause. In other cases, chlamydial organisms may be the cause. In some cases, no organism can be identified as a cause. Symptoms of painful urination along with low grade pelvic pain or low back pain may be present.

Nodular prostatic hyperplasia ((enlargement termed benign prostatic hyperplasia, or BPH) is a common condition as men age. Perhaps a fourth of men have some degree of hyperplasia by the fifth decade of life. By the eighth decade, over 90% of males will have prostatic hyperplasia. However, in only a minority of cases (about 10%) will this hyperplasia be symptomatic and severe enough to require surgical or medical therapy.