Which genes are not good for longevity

Question

which genes are not good for longevity?

I know

daf2, igf1, and others?

Answer 1

Its rather complicated.

Several studies are showing that genes can be beneficial or harmful depending on the tissue and time in which they are active, the presence or absence of other genes, as well as the gender and life history of the individual in whom they reside.

EG. APOE-4, a variant of the apolipoprotein gene associated with Alzheimer's disease, appeared to be slightly correlated with a decreased risk of kidney malfunction after cardiac bypass surgery