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Why are X-linked disorders such as hemophilia generally more common in males?

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Why are X-linked disorders such as hemophilia generally more common in males?

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  1. women have two X chromosomes so if one of them are affected then the other counteracts the affects wheras a male has an X and  a Y so if the X is affected there is not another X to counteract


  2. females have a chance to not show the disorder, yeat remain a carrier for it.. 25% have it 50% carry (but dont show symptoms) 25% not have at all

    males on the other hand only have 1 X chromosome.. so they either have it and can transfer it, or not.. 50-50

  3. X-linked disorders are carried on the X chromosome.

    Females are XX where as Males are XY.

    This means that only one affected X chromosome needs to be inherited for a male to be affected.Where as in females, since they are XX, they need two affected X chromosomes in order to be affected.

    This why X-linked disorders are more common in males.

  4. Since women have two X chromosomes, they typically have the dominant gene on one of the chromosomes to mask the disorder.  In males, however, the X chromosome is paired up with a Y, which is much shorter in length and lacks some of the genes found on the X.  Because the Y chromo is lacking any genes that could cover up the disorder, the disorder is able to manifest itself in the male, making it much easier for guys to get the disorder than girls.

    Hoped that helped!

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