Why are certain gram-negative bacteria more resistant..?

Question

Why are certain gram-negative bacteria more resistant that gram-positive bacteria to antibiotics that attack cytoplasmic targets?

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Answer 1

Although all bacteria have an inner cell membrane, gram-negative bacteria have a unique outer membrane. This outer membrane excludes certain drugs and antibiotics from penetrating the cell, partially accounting for why gram-negative bacteria are generally more resistant to antibiotics than are gram-positive bacteria