If most of the Indian population was wiped out after the Europeans got there and gave them smallpox, why didn't some corresponding Indian disease transfer over to Europe? The lifestyle theory (Indians were more free-roaming and therefore diseases didn't transfer as easily among them) goes some way to explain this, but it's impossible that they would have been entirely disease-free, and also, why didn't they develop certain immunities to European diseases which transfered to humans via animals, some of which were common between the two continents. Also, they had come from Asia originally, so I don't think in 10,000 years they would have changed that drastically from Europeans.
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