Question:

Why does it take 12 hrs for Tylenol PM to wear off?

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Thats how long it takes for me.

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  1. Be it Tylenol PM or any other drug, They all have their effectiveness' time span or period. In the case of Tylenol PM, this pain relieving medication gets completely disolved and used up by the body and therefore, It wears off after 12 hours in your case.

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