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Why does replication proceed in the 5' to 3' direction and not Backwards?

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Why does replication proceed in the 5' to 3' direction and not Backwards?

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  1. Because it reads the template strand which was copied in a 3' to 5' direction. They run antiparallel.


  2. DNA replication always occurs in a 5' to 3' direction because new nucleotides can only be added to the 3' hydroxyl end of the deoxyribose sugar.  The 5' hydroxyl end is bound to the phosphate.
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