Why is phenylpropanolamine cause bleed reaction to a hypertensive patient?

Question

please..i need your helps.........

Answer 1

Phenylpropanolamine is a sympathomimetic drug. This means it constricts the capillaries and arterioles. Its nasal decongestant action is because of that.

It has been found that this drug increases the risk of stroke due to this effect.

In patients who are destined to get a stroke  their arterioles in the brain  are narrowed already due to atherosclerosis or arteiosclerosis.

If this drug narrows them further the pressure in the capillaries increase and they may even rupture leading to bleeding and hence a stroke.

Or such narrowing may slow down the blood flow causing thrombosis.

In a hypertensive patient this tendency is more.

The above drug is not used in UK and has been removed from the British National Formulary