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Why would you not expect to see tissue macrophages in a blood smear?

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Why would you not expect to see tissue macrophages in a blood smear?

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  1. Yeah what he said!


  2. Because tissue macrophages reside in the tissues, not the blood.  You will see a few macrophages though.  Remember that macrophages and neutrophils are only transient residents of the bloodstream, and move out of the circulation and into the tissues relatively quickly (within several hours).
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