Would lack of sleep affect the usefulness of pain killers?

Question

Would lack of sleep affect the usefulness of pain killers?

Answer 1

I am prescribed pain killers from recent back surgery. The pain meds do help alot, but I do get plenty of sleep.   My doctor also prescribes me ambiom to help me fall asleep.  When a person sleeps that is when most of the healing is taking place, because the body is at rest, and healing cells can work better.

Answer 2

Fatigue makes you more susceptible to pain stimuli.  Painkillers will not be as effective if you are tired.