Would there be any difference if I inflated my tires with helium

Question

Would there be any difference if I inflated my tires with helium

Answer 1

The cost to fill up your tires. That's it. ^^

Answer 2

since He is a smaller molecule than the normal molecules in air (O2, CO2, N2, Ar)   the He will seep out faster and make you have to refill your tires more often.   other than that, no difference